Bustin Lab

Protein synthesis extends beyond translation, the process where information encoded in mRNA directs polypeptide formation. After translation, proteins undergo folding and processing which includes the addition of a variety of post-translational modifications (PTMs) that diversify the proteome. These PTMs or other essential machinery, such as cofactors, are often required for protein function or regulation. As our genes do not encode for all these essential protein accessories, many proteins dependent on these moieties are not completely understood. Our group will explore the relationship between protein structure and activity, specifically of certain PTM and cofactor-dependent proteins. We will strive to understand these proteins and their function by exploring their molecular recognition, associated biochemical pathways, and potential roles in disease utilizing chemical tools, enzymatic assays, spectroscopic analysis, and media studies.

View Visiting Assistant Professor Katelyn Bustin's faculty bio.