William (Will) Parsons

(he/him/his)

  • Assistant Professor of Chemistry and Biochemistry

Areas of Study

Education

  • PhD, Stanford University, 2013
  • BA, Williams College, 2007

Chemical biology, small-molecule synthesis, intramembrane hydrolases

Enzyme-mediated hydrolysis is a ubiquitous component of numerous metabolic pathways in the body. Nature has developed a number of chemistries within hydrolase active sites to cleave a diverse array of biological substrates. The Parsons lab studies enzymes that use serine and threonine residues to catalyze turnover of their substrates. A subset of these enzymes with intramembrane active sites are of particular interest due to their unique biochemistry as well as their involvement in pathways underlying metabolic and neurological diseases, including Parkinson’s disease and type 2 diabetes. 

The Parsons lab exploits the active site chemistry of these hydrolases to create new chemical probes for this enzyme class. Drawing upon methodology from synthetic chemistry, biochemistry, molecular biology, and medicinal chemistry, research in the Parsons lab focuses on the development of small molecule tools to study the physiological roles of intramembrane hydrolases.

Parsons teaches general and organic chemistry courses in the department. In the fall semester of 2021, he will be teaching lecture and laboratory sections of CHEM 205: Principles of Organic Chemistry. In the spring semester of 2022, he will be teaching CHEM 325: Organic Mechanism and Synthesis and a laboratory section of CHEM 205.

(Note: An asterisk indicates an Oberlin student/graduate co-author)

  • Parsons WH, Rutland NT*, Crainic JA*, Cardozo JM*, Chow AS*, Andrews CL*, Sheehan BK*. Development of succinimide-based inhibitors for the mitochondrial rhomboid protease PARL. Bioorg Med Chem Lett. 2021: 128290. doi: 10.1016/j.bmcl.2021.128290.
  • Lin Z, Wang X, Bustin KA, Shishikura K, McKnight NR, He L, Suciu RM, Hu K, Han X, Ahmadi M, Olson EJ, Parsons WH, Matthews ML. Activity-based hydrazine probes for protein profiling of electrophilic functionality in therapeutic targets. ACS Cent Sci. 2021. doi: 10.1021/acscentsci.1c00616.
  • Erikci Ertunc M, Kok BP, Parsons WH, Wang JG, Tan D, Donaldson CJ, Pinto AFM, Vaughan JM, Ngo N, Lum KM, Henry CL, Coppola AR, Niphakis MJ, Cravatt BF, Saez E, Saghatelian A. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. J Biol Chem2020, 295, 5891–5905. doi: 10.1074/jbc.RA119.012145.
  • Chen AL, Lum KM, Lara-Gonzalez P, Ogasawara D, Cognetta AB III, To A, Parsons WH, Simon GM, Desai A, Petrascheck M, Bar-Peled L, Cravatt BF. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nat Chem Biol. 2019, 15, 453–462. doi: 10.1038/s41589-019-0243-4.
  • Parsons WH, Kolar MJ, Kamat SS, Cognetta AB III, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol. 2016, 12, 367–372. doi: 10.1038/nchembio.2051.

See a complete list of published work

Notes

William Parsons publishes with six recent graduates

August 4, 2021

William Parsons, assistant professor of chemistry and biochemistry, and six recent Oberlin graduates (Charlotte Andrews '19, Joaquin Cardozo '20, Alyssa Chow '20, Jennifer Crainic '20, Nicholas Rutland '20, and Brendan Sheehan '19) published an article title "Development of succinimide-based inhibitors for the mitochondrial rhomboid protease PARL" in Bioorganic & Medicinal Chemistry Letters.

News

Winter Term in Oberlin: 2020

February 24, 2020

Winter Term is a time of year when Oberlin students are encouraged to conduct independent or group projects outside of courses related to their majors. Pursuits can be done on or off campus with students choosing to work almost anywhere on the map. This year we highlight some of the work by the more than 900 students who completed projects in Oberlin.

This Week in Photos: January 22

January 22, 2020

In this photo series, we explore the art of cinema storytelling; go to an entrepreneurial boot camp; get intense with strings and Greek; go back to high school in Berkeley; stop by the freezer section in Kim’s Grocery & Carryout; get involved with dark matter; learn R for SPSS; join a dance class; design an archeological exhibit; get cozy with a wild beast; and much more.