Lisa Ryno

  • Associate Professor of Chemistry and Biochemistry

Areas of Study


  • BS, Trinity University, 2008
  • PhD, The Scripps Research Institute, 2012


Professor Ryno’s teaching interests are biochemistry, bioorganic chemistry, and general chemistry.

Research in the Ryno lab utilizes techniques in molecular biology, microbiology, and biochemistry and focuses on exploring new methods to mitigate antibiotic resistance. A considerable amount of effort is being placed in the development and discovery of antibiotics that not only inhibit general bacterial viability but also target particular mechanisms of virulence such as toxin function, delivery and adhesion of bacteria. Despite the numerous advances in antibiotic development, the rapid evolution of bacterial resistance to different mechanisms of antibiotic treatment calls for a constant influx of bactericidal agents that work through novel mechanisms.

The Ryno lab studies the problem of antibiotic resistance from two separate angles. We will explore small molecule inhibitors of specific chaperones involved in the protein homeostasis of the periplasm, and we will also investigate specific pathways in Gram-negative bacteria that are involved in stress-responsive signaling and their impact on the formation of biofilm.


Oberlin College News: The Research You Cannot Resist

Research interests include antibiotic resistance, stress-responsive signaling, and chaperone-client protein-protein interactions.

Fall 2024

Biochemistry — CHEM 374

Spring 2025

Principles of Chemistry — CHEM 102


Lisa Ryno Awarded Grant from the National Science Foundation

September 29, 2022

Associate Professor of Chemistry and Biochemistry Lisa Ryno was recently awarded a grant from the National Science Foundation, "Sugar-mediated remodeling of the E. coli transcriptome and its impact on biofilm growth and composition." This $534,002 grant will support student-faculty research on how monosaccharides influence both biofilm growth and composition. Because biofilms play a role in antibiotic resistance, better understanding of the biochemical pathways through which they form could have eventual applications in development of antibiotics or antibiofilm coatings.

Lisa Ryno Publishes Article

December 16, 2021

Luke Buck '21, Maddison Paladino '21, Kyogo Nagashima '24, Emma Brezel '17, Josh Holtzman '21, and Sarel J. Urso '16 coauthored a publication with Associate Professor of Chemistry and Biochemistry Lisa Ryno in Frontiers in Cellular and Infection Microbiology titled "Temperature-dependent influence of FliA overexpression on PHL628 E. coli biofilm growth and composition."

Lisa Ryno gives keynote presentation on undergraduate research at alma mater Trinity University

August 4, 2021

Assistant Professor of Chemistry and Biochemistry Lisa Ryno gave the keynote presentation, "The Impact of Undergraduate Research: A Personal Vignette" for Trinity University's 2021 Summer Experiential Learning Symposium. An alumna of TU (Class of 2008), Ryno was honored to reflect on some of the most meaningful aspects of undergraduate research as a student and how she now applies them as a mentor to undergraduate researchers in her lab.

Lisa Ryno Publishes Blog Entry

June 11, 2019

Assistant Professor of Chemistry and Biochemistry Lisa Ryno published a blog post titled "Tackling Summer Boredom" on the Council on Undergraduate Research's Division of Chemistry website.

Cottine and Ryno Co-author

September 19, 2018

Assistant Professor of Religion Cheryl Cottine and Assistant Professor of Chemistry and Biochemistry Lisa Ryno co-authored the article "Biological Impact and Ethical Implications of Pesticide Use: A Short Module for Upper-Division-Undergraduate Biochemistry Courses" published in the Journal of Chemical Education.

Lisa Ryno Receives Award

February 16, 2018

Lisa Ryno, assistant professor of chemistry and biochemistry, received the Research Corporation for Science Advancement Cottrell Scholar Award for her proposal, "Investigating the Impact of fliA Overexpression on the Formation and Composition of E. coli Biofilms at Different Temperatures." Ryno was one of 24 who received this $100,000 award given to early career academic scientists to use at their discretion for research and teaching.