- Associate Professor of Neuroscience
- Chair of Neuroscience
- BS, University of British Columbia, Vancouver BC, Canada 1999
- MA, Queen's University, Kingston ON, Canada 2001
- PhD, Queen's University, Kingston ON, Canada 2004
Tracie Paine is a behavioral neuroscientist whose research uses a combination of behavioral and molecular biological techniques to investigate the neurobiology of cognitive functions such as attention and impulse control.
Attention and impulse control are dysregulated in a number of psychiatric conditions including schizophrenia, attention-deficit hyperactivity disorder (ADHD) and substance abuse. Thus, understanding the neurobiology of these cognitive functions will ultimately lead to the development of novel, more effective treatment strategies for these conditions.
Paine has been awarded National Alliance for Research on Schizophrenia and Depression (NARSAD) Young investigator awards (2006, 2009) in order to pursue research investigating cortical cell signaling pathways and neural circuits regulating attention and impulse control. Her most recent publications appear in the journals Neuropsychopharmacology, Neuropharmacology and Biological Psychiatry.
Neuropharmacology, Behavioral Neuroscience, Attention, Impulse control, Substance Abuse
Paine TA, Swedlow N^, Swetschinski L^ (2017). Decreasing GABA function within the medial prefrontal cortex or basolateral amygdala decreases sociability. Behavioral Brain Research, 317, 542-552. doi: 10.1016/j.bbr.2016.10.012.
Paine TA, Cooke EK^, Lowes DC^ (2015). Effects of chronic inhibition of GABA synthesis on attention and impulse control. Pharmacology, Biochemistry and Behavior, 135, 97-104. doi: 10.1016/j.pbb.2015.05.019.
Paine TA, O’Hara A^, Lowes DC^, Plaut B^ (2015). Effects of disrupting medial prefrontal cortex GABA transmission on decision-making in a rodent gambling task. Psychopharmacology, 232, 1755-1765. doi: 10.1007/s00213-014-3816-7
Asinof SK^, Paine TA (2014). The 5-choice serial reaction time task: A task of attention and impulse control for rodents. The Journal of Visualized Experiments, 90. doi: 10.3791/51574 http://www.jove.com/video/51574/the-5-choice-serial-reaction-time-task-task-attention-impulse-control
Paine TA, Asinof SK^, Diehl GW^, Frackman A^, Leffler J^ (2013). Medial prefrontal cortex lesions impair decision-making on a rodent gambling task: reversal by D1 receptor antagonist administration. Behavioural Brain Research, 243, 247-254. doi: 10.1016/j.bbr.2013.01.018
Diehl GW^, Wachtel JM^, Paine TA (2013). Cue-induced conditioned activity does not incubate but is mediated by the basolateral amygdala. Pharmacology, Biochemistry and Behavior, 104, 69-79. doi: 10.1016/j.pbb.2013.01.003
Asinof SK^, Paine TA (2013). Inhibition of GABA synthesis in the prefrontal cortex increases locomotor activity but does not affect attention in the 5-choice serial reaction time task. Neuropharmacology, 65, 39-47. doi: 10.1016/j.neuropharm.2012.09.009