Shuming Chen

  • Assistant Professor of Chemistry and Biochemistry

Areas of Study

Education

  • BA, Grinnell College, 2011
  • PhD, Yale University, 2016

Modern computational chemistry has enabled chemists to obtain atomic-level insights, especially reactive intermediates, and transition state structures that are difficult to study by other means. Our lab seeks to generate fundamental mechanistic understanding, and use it to design new chemical reagents with improved efficacy and selectivity. 

Oberlin undergraduate student coauthors are underlined:

• Ji, P.; Davies, C. C.; Gao, F.; Chen, J.; Meng, X.; Houk, K. N.*; Chen, S.*; Wang, W.* Selective Skeletal Editing of Polycyclic Arenes Using Organophotoredox Dearomative Functionalization. Nat. Comm.2022, 13, 4565.

• Han, F.; Choi, P. H.; Ye, C.-X.; Grell, Y.; Xie, X.; Ivlev, S. I.; Chen, S.*; Meggers, E.* Cyclometalated Chiral-at-Ruthenium Catalyst for Enantioselective Ring-Closing C(sp3)–H Carbene Insertion to Access Chiral Flavanones. ACS Catal. 2022, 12, 10304.

• Kazerouni, A. M.; Brandes, D. S.; Davies, C. C.; Cotter, L. F.; Mayer, J. M.*; Chen, S.*; Ellman, J. A.* Visible Light-Mediated, Highly Diastereoselective Epimerization of Lactams from the Most Accessible to the More Stable Stereoisomer. ACS Catal.2022, 12, 7798.

• Lv, L.*; Qian, H.; Crowell, A. B.; Chen, S.*; Li, Z*. Pd/NHC-Controlled Regiodivergent Defluorinative Allylation of gem-Difluorocyclopropanes with Allylboronates. ACS Catal. 2022, 12, 6495.

Gao, A. Z.; Chen, S.* Mechanism and Selectivities in Ru-Catalyzed Anti-Markovnikov Formal Hydroalkylation of 1,3-Dienes and Enynes: A Computational Study. J. Org. Chem. 2021, 86, 11895.

• Zhang, C.; Gao, A. Z.; Nie, X.; Ye, C.-X.; Ivlev, S. I.; Chen, S.*; Meggers, E.* Catalytic α-Deracemization of Ketones Enabled by Photoredox Deprotonation and Enantioselective Protonation. J. Am. Chem. Soc.2021, 143, 13393.

Fall 2022

Principles of Organic Chemistry — CHEM 205
Synthesis Laboratory — CHEM 327

Spring 2023

Principles of Organic Chemistry — CHEM 205

Notes

Shuming Chen publishes Article in ACS Catalysis

September 7, 2022

Assistant Professor of Chemistry and Biochemistry Shuming Chen recently published an article in ACS Catalysis, "Cyclometalated Chiral-at-Ruthenium Catalyst for Enantioselective Ring-Closing C(sp3)–H Carbene Insertion to Access Chiral Flavanones." Co-authors include Peter Choi '23 and collaborators in Marburg, Germany.

Shuming Chen Paper Published in "Nature Communications"

August 16, 2022

Assistant Professor of Chemistry and Biochemistry Shuming Chen recently published a paper in Nature Communications, "Selective skeletal editing of polycyclic arenes using organophotoredox dearomative functionalization." Co-authors on the article include Cassie Davies ’24 and collaborators from UCLA and the University of Arizona.

Shuming Chen Co-Authors Research in 'Nature Chemistry' Journal

April 7, 2022

Assistant Professor of Chemistry and Biochemistry Shuming Chen co-authored a research article in Nature Chemistry with Professor Eric Meggers' research group at the University of Marburg, Germany. This collaborative experimental and computational study reveals that non-covalent interactions, such as π–π stacking, hold the key to stereocontrol (control over three-dimensional shapes of molecules) in a novel synthesis of chiral α-amino acids catalyzed by ruthenium and iron complexes.

Shuming Chen publishes two research articles with Anthony Gao '21

August 20, 2021

Assistant Professor of Chemistry and Biochemistry Shuming Chen and Anthony Gao '21 published two research articles on transition-metal catalysis: "Mechanism and Selectivities in Ru-Catalyzed Anti-Markovnikov Formal Hydroalkylation of 1,3-Dienes and Enynes: A Computational Study" in the Journal of Organic Chemistry; and "Catalytic α-Deracemization of Ketones Enabled by Photoredox Deprotonation and Enantioselective Protonation" in the Journal of the American Chemical Society. The latter work was published in collaboration with Professor Eric Meggers' research group at the University of Marburg, Germany.