"Nanoscale Membrane Curvature Revealed by Super-Resolution Microscopy" is the title of the talk to be presented by Christopher V. Kelly ’03, assistant professor of physics at Wayne State University.
Abstract: Many essential biological processes occur at length scales that are unresolvable by conventional optical microscopes. We have combined super-resolution microscopy methods to measure the interdependence of molecular organization, lipid phases, and curvature on biological membranes.
We have measured membrane curvature as small as 20 nm radii of curvature, measured curvature-induced molecular sorting, and a local change in the local membrane viscosity. Further, we have discovered that the membrane-binding toxin of cholera self-assembles to form nanoscale membrane buds to facilitate its immobilization and internalization into cells.
We will discuss the physics of polarized localization microscopy and the mechanisms by which cholera toxin bends membranes.
A reception for Professor Kelly begins at 4:10 p.m. in the Anderson Lounge, Wright Lab, second floor.