The Department of Chemistry and Biochemistry hosts guest speaker Richard van Breemen '80, director of the Linus Pauling Institute at Oregon State University, whose topic will be "From the Field to the Clinic, the Role of Mass Spectrometry in Establishing Safety and Efficacy of Botanical Dietary Supplements."
The seminar will be preceded by a reception at 4:30 p.m., in the David Love Lounge.
Sponsored by the Ralph F. Hirschmann Lectureship Fund.
Mass spectrometry has become an essential tool for all stages of drug discovery and development. Similarly, mass spectrometry has broad utility in studies of the safety and efficacy of botanical dietary supplements.
Such applications to botanical dietary supplements include studies of the mechanisms of action (target identification and validation); identification of active natural products (drug discovery); studies of metabolism of active compounds; investigation of the potential for drug-botanical interactions (similar to studies of drug-drug interactions); and investigation of the pharmacokinetics of active compounds.
Mass spectrometry is also being used in support of Phase I, II and III clinical trials of safety and efficacy of botanical dietary supplements. Preclinical and clinical examples will be drawn from studies of botanical dietary supplements such as red clover, black cohosh, hops, and licorice that are being used by menopausal women as alternatives to conventional hormone therapy.