The Department of Chemistry and Biochemistry hosts guest speaker Rae M. Eaton ’13, graduate student in the Bush lab at the University of Washington. Her topic will be ‘‘Native Ion Mobility Mass Spectrometry: New(ish) Instrumentation to Address a Structural Biology Problem.‘‘
The seminar will be preceded by a light reception at 4:30 p.m. in the David Love Lounge.
Sponsored by the University of Washington
Traditional structural biology tools often provide limited information about the native conditions of proteins and their higher-order assemblies. In the Bush group we use native ion mobility mass spectrometry (IMMS) to obtain information on the size, shape, and stoichiometry of proteins and protein complexes.
New ion mobility instrumentation, created using printed circuit board technologies, was implemented to increase the amount of information available in an IMMS experiment. The expansion of this new technology to tandem IM experiments enabled the study of protein structural evolution in the gas phase and gave insight into the relationship between native-like, solution- and gas-phase proteins.