The Department of Chemistry and Biochemistry hosts guest speaker Ellen M. Sletten, assistant professor in the Department of Chemistry and Biochemistry at the University of California at Los Angeles, whose topic will be "Enhancing Therapeutics and Diagnostics with Fluorine."
The seminar will be preceded by a reception at 4:30 p.m., in the David Love Lounge.
Sponsored by the Luke E. Steiner Lecture Fund.
Perfluorinated materials have unique, abiotic properties, making perfluorination a promising handle to control chemical events in vivo.Perfluorocarbon nanoemulsions are droplets of fluorous solvent stabilized in water by surfactants.These emulsions have previously been FDA-approved for oxygen delivery and since employed for 19F-magnetic resonance and ultrasound imaging. We transform perfluorocarbon nanoemulsions into responsive, multifunctional nanomaterials by imparting custom surfactants and fluorous chromophores. We have previously shown that photoactive molecules can be localized inside the nanoemulsions by introducing fluorous-tagged fluorophores prior to assembly. The enhanced photophysical properties of chromophores and fluorophores in perfluorinated solvent render these nanomaterials ideal agents for optical imaging and phototherapies. I will discuss our results regarding targeted imaging and photodynamic therapy with these multifunctional perfluorocarbon nanoemulsions.